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#1 Stokr89

Posted

hey everyone,

 

I need some opinions/advice on this:

I am currently trying to get rid of gyno that flared up during PCT of a 8week Halodrol  cycle. I basically extended the PCT by using Nolva for 9 weeks or so. I didn't really help in reducing the tissue, so I decided to toss in some AI.

I got Aromasin, which I'm running @ 12.5 mgs ED (morning) + Nolva @ 20 mg ED (evening). Both are pharma grade (Xtane & Mamofen) and not expired.

 

When I take Aromasin, pain and swelling go away almost completely within 1 hour. The weird stuff happens when I take nolva: after 20 minutes or so, soreness and puffiness come back. 

 

what do you think? should I drop/reduce the Nolva?

 

cheers


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#2 Svartnir

Posted

This makes no sense whatsoever. Only thing I can think of is prolactin being the cause of gyno? I think Nolva does nothing for those cases, and means Raloxifen might be a better choice. It might be nontheless since I've seen many guys had success with ralox+letro

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#3 tvhatic grade

Posted

Nolva and SERMs in general block estrogen at ER alpha sites. However, it actually acts as an estrogen at ER beta sites.

 

The majority of ER receptors in breast tissue are ER alpha, which is why Nolva is normally a great treatment for gyno and breast cancer. That being said, when Nolva doesn’t work in treating breast cancer, it is often due to the over expression of a certain type of estrogen receptor. Theoretically, difficult to treat gyno development may follow a similar path.

 

Another option is you may have prolactin induced gyno. Anecdotal reports and a lot of internet bro scientists have claimed Nolva will make gyno worse if it is prolactin induced, as prolactin gyno requires some estrogen action to grow (and Nolva activating one of the E receptors facilitates this). I do not know if this is accurate though.

 

The third option is just because you order something from an Indian pharmacy does not mean it is 100% pharma grade. Although most of my orders from these pharmacies have been legit, I know I did receive one product from a reputable Indian pharmacy that looked legit but was 100% fake. Just something to consider… Indian Pharma is not the same as US pharma. 


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#4 allergy man

Posted

Have you had blood work done yet? Might be very useful since this has been going on for so long. Something unexpected may be out of whack and causing these issues. If nothing else it will help eliminate some potential variables. It seems like most of what you have done is based off of what we bro scientists perceive as a potential issue without any actual personal data to you specifically. I also wouldn't trust the Indian pharm stuff as being 100% legit, it very well could be bunk, underdosed or a totally different compound than you think.

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#5 villie

Posted

Nolva works in the body as an estrogen on the receptor site. doctor told me once that it could worsen the problem

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#6 Stokr89

Posted

I'm starting to think that tvhatic is right...I might have got a bunk batch of Nolva...today I used the new pills (same pharma brand) and nothing bad happened. 

 

@tvhatic how did you know it was 100% fake? got it tested?
 


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#7 tvhatic

Posted

I'm starting to think that tvhatic is right...I might have got a bunk batch of Nolva...today I used the new pills (same pharma brand) and nothing bad happened. 

 

@tvhatic how did you know it was 100% fake? got it tested?
 

The fake product I got from this Indian pharmacy was Tadacip (cialis). It had legit packaging, production codes ect. However, 1 pill did nothing. Next day, I took 4 pills and no effect, whatsoever.

 

Their Altraz (anastrozole) was legit though (verified with bloodwork). So, next time I ordered more Altraz, I also ordered a diff generic cialis, Forezt. This one is legit. 1 pill causes effect for days.  


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#8 Stokr89

Posted

fd up stuff...that's probably why I developed gyno during pct in the first place


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#9 poopypants

Posted

Brand of nolva please?

Luuurkin...

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#10 Stokr89

Posted

Mamofen, by Khandelwal Laboratories


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#11 poopypants

Posted

Mmk.

Luuurkin...

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#12 tvhatic

Posted

Reviewing SERM literature for an unrelated subject, I came across this:

 

http://www.ncbi.nlm..../pubmed/6542011

 

Apparently, it is common to have a “Flare” when beginning Nolva therapy for breast cancer. This is due to low levels of the drug being estrogenic, however treatment should continue as once levels rise, it is highly anti-estrogenic.

 

I was surprised to see this. I would bet your Nolva is legit and this initial flare is what you are seeing. 


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#13 Stokr89

Posted

Reviewing SERM literature for an unrelated subject, I came across this:

 

http://www.ncbi.nlm..../pubmed/6542011

 

Apparently, it is common to have a “Flare” when beginning Nolva therapy for breast cancer. This is due to low levels of the drug being estrogenic, however treatment should continue as once levels rise, it is highly anti-estrogenic.

 

I was surprised to see this. I would bet your Nolva is legit and this initial flare is what you are seeing. 

wow this is very interesting. Although it doesn't really make sense in a context of PCT, which is way shorter that a cancer treatment protocol, otherwise we would all develop gyno during pct if our nolva required a longer period to reach steady blood levels..so either it is something that happens completely randomly or my nolva was bunk. 


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#14 grenadine

Posted

I used mamofen tamox before. It seemed a little underdosed but worked. Indian pharmacies can be sketch.

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Source: http://www.prohormoneforum.com/index.php/topic/87872-nolva-makes-my-gynoworse/


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